Relatedly, the TNFR2 oncogene expression on ovarian tumor cells render them susceptible to death by TNFR2 antagonism: TNFR2 antagonistic antibodies in vitro directly kill TNFR2-expressing ovarian cancer cell lines, kill the tumor-associated TNFR2+ Tregs, and proliferate the beneficial T effectors (Teffs) [12, 13]. This evidence concerns the gene TNFRSF1B and ovarian carcinoma.