In 2013 the Cancer Genome Atlas (TCGA) group published results of an extensive genomic characterisation of endometrial cancer, defining four different molecular subgroups with distinct prognosis: a POLE-ultramutated group; a microsatellite-unstable hypermutated group; a copy-number-low group and a copy-number-high group driven by TP53 mutation10. Here, TP53 is linked to endometrial cancer.