In 2013 the Cancer Genome Atlas (TCGA) group published results of an extensive genomic characterisation of endometrial cancer, defining four different molecular subgroups with distinct prognosis: a POLE-ultramutated group; a microsatellite-unstable hypermutated group; a copy-number-low group and a copy-number-high group driven by TP53 mutation10. The gene discussed is POLE; the disease is endometrial cancer.