To test whether the pivotal oncoprotein HPV16/18 E7-mediated LDHA nuclear translocation, we packaged retrovirus containing HPV16/18 E7 gene and infected primary human cervix keratinocytes (PHKs), immortalized human keratinocyte cell line HaCaT, and transfected HPV16 E7 gene into HPV-negative human cervical cancer cell line HT-3 (Supplementary Fig. 2a). This evidence concerns the gene LDHA and cervical cancer.