To further define the clinical relevance of our findings that HPV16 E7-induced LDHA nuclear translocation activated antioxidant response and Wnt signaling pathway, IHC analyses were performed to examine HPV16 E7 expression, LDHA nuclear localization, and H3K79 trimethylation levels in serial sections of 52 cases of human primary cervical cancer specimens. The gene discussed is LDHA; the disease is cervical carcinoma.