KCNJ10 and Seizure: Regarding the pathophysiological alterations of Kir4.1 channels in epilepsy, previous studies showed that brain Kir4.1 expression was down-regulated in animal models of convulsive seizures, including DBA/2 mice [60,61], Noda epileptic rats (NER) [62], a post-traumatic epilepsy model [63], and an albumin-induced seizure model in rats [64], but not in a model of absence seizures (Groggy rats) (Table 1) [65].