As shown in Table 3, the risk of hypoglycemia was higher for the diabetic patients with the medications of sulfonylurea (HR = 1.76, 95% CI = 1.19–2.60), metformin (HR = 1.66, 95% CI = 1.14–2.43), insulin (HR = 1.78, 95% CI = 1.26–2.52) and loop diuretics (HR = 1.33, 95% CI = 1.01–1.76) but lower for those with only AIIRBs (HR = 0.71, 95% CI = 0.54–0.93). This evidence concerns the gene INS and Hypoglycemia.