An rs738409 C>G variant in the patatin-like phospholipase domain-containing 3 (PNPLA3) gene, encoding an I148M mutation, was the first allele associated with intrahepatic fat content and appears to be a major genetic determinant of hepatic steatosis and the progression of fatty liver disease[15–16]. The gene discussed is PNPLA3; the disease is Hepatic steatosis.