An rs58542926 C>T variant in the transmembrane 6 superfamily member 2 (TM6SF2) gene, encoding an E167K mutation, and an rs780094 C>T variant in the glucokinase regulator (GCKR) gene were later shown to be associated with both hepatic steatosis and the risk of progression to fibrosis[17–20]. This evidence concerns the gene GCKR and fatty liver disease.