PNPLA3 and metabolic dysfunction-associated steatotic liver disease: Probably for this reason, the rs641738 C>T variant of MBOAT7, which results in decreased hepatic MBOAT7 expression, has not been observed to increase the risk of steatosis to the degree of PNPLA3 or TM6SF2. Rather, the rs641738 C>T variant of MBOAT7 is associated with an increase in hepatic inflammation and fibrosis in NAFLD[21,48–49].