Several tumor suppressor genes, including CDKN2A[13–15], MGMT[13,16], APC[17], CD-H1[13], DAPK[13], FHIT[18], RASSF1A[19], CDH13[20], BRCA1[13], CHFR[21] and SST[22] have been reported as hypermethylated in ESCC. Here, CDH13 is linked to esophageal squamous cell carcinoma.