In this context, it would be intriguing to note that a number of paraspeckle-enriched RBPs with IDRs, including SFPQ, FUS, EWSR1, TAF15, TDP-43, SS18L1 and HNRNPA1, are mutated in familial cases of amyotrophic lateral sclerosis (ALS) and other neurodegenerative diseases [26,67–71]. Here, EWSR1 is linked to amyotrophic lateral sclerosis.