We previously identified the megalin gene as a target of miR-148b and showed that transfection of renal proximal tubule cells with miR-148b in vitro caused a down-regulation of megalin mRNA and protein expression, indicating that miR-148b may be involved in the regulation of proximal tubule protein reabsorption in renal disease conditions with increased levels of miR-148b [17]. The gene discussed is LRP2; the disease is kidney disorder.