Integrin αvβ6 induced secretion of MMP-3 in the absence or presence of co-cultured CAFs (*P<0.05); meanwhile, the CAFs also significantly induced MMP-3 secretion from CRC cells in the presence (**P<0.01) or absence (*P<0.05) of β6 expression, as shown in Figure 4C. Integrin αvβ6 also induced secretion of MMP-9 in the absence or presence of co-cultured with CAFs (*P<0.05); the CAFs also significantly induced MMP-9 secretion from HT-29 CRC cells and RKO β6 overexpression CRC cells (**P<0.01 and ***P<0.001, respectively). Here, MMP9 is linked to colorectal carcinoma.