Overexpression of HIF-1α is related to the increased patient mortality in human cancers, particularly in cancers of the bladder, brain, breast, cervix, endometrium, oropharynx, lung, skin, and stomach, which manifests the inhibition of HIF-1α is crucial in the treatment of many diseases including corneal diseases [23]. This evidence concerns the gene HIF1A and urinary bladder carcinoma.