Although considered to be the most frequently mutated nucleotide in the germline with a birth prevalence of about 1:30,000 (Bellus et al. 1995), we did not detect the FGFR3 c.1138G > A or c.1138G > C achondroplasia-associated mutations due to exclusion of this region because of insufficient coverage (less than 5000×) (Supplemental Table S2; Supplemental Fig. S3E). Here, FGFR3 is linked to achondroplasia.