We observed 12 distinct variants located within the N-SH2 domain of SHP2, a region of the protein known to repress the catalytic phosphatase domain in its wild-type state (Neel et al. 2003), including each of the possible nucleotide substitutions at PTPN11 c.215C encoding three distinct amino acids (p.Ala72Asp, p.Ala72Gly, and p.Ala72Val) that have been associated with Noonan syndrome or oncogenesis. Here, PTPN11 is linked to Noonan syndrome.