Moreover, CD4+ T cell-derived cytokines, such as IL-17, can promote the direct expression of VEGF in human cancer cells (Pan et al., 2015), and TAM and TAN-derived ECM remodeling enzymes, such as MMP9, can induce the release of pro-angiogenic factors that are trapped in the ECM (Lee et al., 2005). The gene discussed is CD4; the disease is cancer.