These include neutrophil accumulation in the blood (Templeton et al., 2014), clusters of VEGFR1+ cells detected in common sites of metastasis before tumor spread (Kaplan et al., 2005), elevated MMP9 levels in the lungs of patients with distant tumors (Hiratsuka et al., 2002), and LOX and CD11b+ cells in metastatic tissues (Erler et al., 2009). The gene discussed is ITGAM; the disease is neoplasm.