For instance, TAMs could be re-educated into an anti-tumor phenotype by CSF-1R inhibition or by pattern recognition receptor (PRR; Box 1) ligands, which inhibited tumor growth in a mouse model of glioblastoma multiforme (Pyonteck et al., 2013) and lung cancer (Shime et al., 2012), respectively. Here, CSF1R is linked to neoplasm.