CXCR2 and familial pancreatic carcinoma: Similarly, disruption of neutrophil recruitment through CXCR2 blockade prevented metastasis formation in cell line, xenograft and spontaneous models of rhabdomyosarcoma, colon and pancreatic cancer (Highfill et al., 2014; Steele et al., 2016; Wang et al., 2017), and several CXCR2 inhibitors are currently under clinical investigation.