VIM and Alexander disease: RFs in AxD patients andtransgenic mouse models contain the small heat shock proteinαB-crystallin (Heaven et al.,2016; Iwaki et al., 1989).Super-resolution stimulated emission depletion (STED) imaging showed thatαB-crystallin and vimentin co-localized with non-filamentous, punctateGFAP in both AxD mutant lines (Figures 2Band S2A).