ERVW-1 and HIV-1 infection: Our finding that a complete glycan shield at transmission favors the development of neutralization breadth during HIV-1 infection seems at odds with previous findings that removal of certain glycans facilitates Env binding to germline precursors of several bNAb classes, e.g., N276 for VRC01-class precursors (Stamatatos et al., 2017), N130 and N185 for V2 glycan bNAb precursors (Voss et al., 2017), and V1 glycans for PGT121 precursor (Steichen et al., 2016).