It is also located on chromosome 3 p like VHL and PBRM1. SETD2 mutations are subclonalin ccRCC tumors (Gerlinger et al., 2012; Gerlinger et al., 2014; Sankin et al., 2014), and are associated with worse patient survival (Hakimi et al., 2013). This evidence concerns the gene PBRM1 and nonpapillary renal cell carcinoma.