However, the PET results have been inconsistent, with one study using the tracer [11C]-PBR28 showing an elevation in relative TSPO binding in people at ultra high risk of psychosis using the ratio but not with the VT approach (Bloomfield et al., 2016b), while two studies using VT as the outcome measure, using the tracer [18F]-FEPPA and [11C]-PK11195, showed no differences in TSPO binding between healthy controls and in individuals at ultra high risk of psychosis for psychosis (Hafizi et al., 2016; Di Biase et al., 2017). The gene discussed is TSPO; the disease is psychotic disorder.