IL1B and schizophrenia: Moreover, studies of cerebrospinal fluid (CSF) have shown increased levels of pro-inflammatory markers in schizophrenia patients when compared with healthy controls, including IL-1β, IL-6 and S100B (Schmitt et al., 2005; Soderlund et al., 2009; Sasayama et al., 2013; Schwieler et al., 2015).