In line with the above theory, the induced antibodies were able to label both brain extracts and histological preparations from AD and non-AD tauopathies, indicating that the conformational epitope in the microtubule-binding region of tau that is targeted by AADvac1 is both present and accessible in all evaluated forms of tau pathology (AD, PSP, CBD, Pick’s disease). Here, MAPT is linked to Alzheimer disease.