The amyloid cascade hypothesis is supported by the fact that mutations in the amyloid precursor protein and the presenilins involved in its processing can cause AD in an autosomal dominant fashion [7]; the tau hypothesis draws its support from the observation that brain atrophy and cognitive and functional impairment in AD are directly tied to the amount and localisation of tau pathology [2, 6, 8]. This evidence concerns the gene MAPT and Alzheimer disease.