MAPT and frontotemporal dementia: In line with the above theory, the induced antibodies were able to label both brain extracts and histological preparations from AD and non-AD tauopathies, indicating that the conformational epitope in the microtubule-binding region of tau that is targeted by AADvac1 is both present and accessible in all evaluated forms of tau pathology (AD, PSP, CBD, Pick’s disease).