ADIPOQ and gestational diabetes: Specifically, early in-life alterations of the DNA methylation pattern might lead to long-term dysregulation of gene expression, e.g., for ADIPOQ. Bouchard et al. [22] showed that maternal glucose levels at GDM screening are associated with placental DNA methylation of ADIPOQ. This may indicate that materno-fetal (hyper)glycemia is involved in the programming of DNA methylation signatures.