2017). Saffron and its active ingredients have been known to treat anxiety, depression and other mental disorders due to their effect in modulating neurotransmitter releases, which are a less toxic and more favorable outcome (Shafiee et al. 2018). SAF also has obvious anti-Parkinson effects including inhibiting a-LA, increasing TH + cells count indicating SAF pretreatment saved many dopaminergic cells in the SNc and retina in MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine)-induced PD animal model (Khazdair et al. 2015). Here, TH is linked to major depressive disorder.