In mucositis, IL‐6, together with TNF‐α and IL‐1β, was found to be significantly increased both in blood and intestinal tissue in animal models and patients.53, 54, 55 Especially IL‐6 levels correlate with the severity of the inflammation,56 and reduction of IL‐6 attenuates intestinal inflammation.57 Here, we found that Wheat 1 was able to inhibit the HKLM induced IL‐6 production in DCs. This evidence concerns the gene TNF and mucositis.