Such as PFKP, which has already identified as a lung cancer oncogene based on its SNP and mRNA expression profile data.39 However, among these ten genes described above, only SERPINB5 was reported its abnormal expression in lung cancer due to aberrant DNA methylation and none of them were studied the correlation between their expression level and prognosis of LUAD patients. This evidence concerns the gene PFKP and lung carcinoma.