Very recently, one study discovered overexpressed SPON2 in hepatocellular carcinoma could promote macrophages recruitment and prevent metastasis of hepatocellular carcinoma cells.28 Strikingly, WNT7A was down regulated, via promoter methylation, in many NSCLC cell lines and tissues,29 which in accordance with the results of DNA methylation and mRNA expression analysis. This evidence concerns the gene WNT7A and hepatocellular carcinoma.