IL‐1β also stimulates angiotensin II type 1 receptor and reactive oxygen species (ROS) production in many kinds of pathological conditions, then enhancing glutamatergic excitatory and attenuating GABAergic inhibitory activities from sympathetic neurons.52, 53 It was reported in heart failure and hypertensive rat models which may be also applied in MI rats. This evidence concerns the gene AGTR1 and hypertensive disorder.