IL‐1β also stimulates angiotensin II type 1 receptor and reactive oxygen species (ROS) production in many kinds of pathological conditions, then enhancing glutamatergic excitatory and attenuating GABAergic inhibitory activities from sympathetic neurons.52, 53 It was reported in heart failure and hypertensive rat models which may be also applied in MI rats. Here, IL1B is linked to heart failure.