CLEC4E and Ventricular arrhythmia: Knockdown Mincle could induce a reduction in NE in the myocardium, and the ventricular arrhythmia score was reduced, supporting the concept that the VF threshold could be reduced when confronted with sympathetic blockade or vagal up‐regulation in animal studies.39 We further explored the mechanism of the PVN Mincle in sympathetic activation.