BMI1 and cancer: ZO‐1 is a cell‐cell tight junction protein and a marker of cell motility24 While Twist and Bmi1 are also reported to closely correlate with migration and invasion of cancer cells.25, 26 IL‐17A treatment significantly decreased ZO‐1 expression but increased the expressions of Twist and Bmi1 in U251 and U87 cells compared to the untreated control group (*P < 0.05, **P < 0.01) (Figure 3A and B).