MMP‐2/9 plays an important role in cancer metastasis,23 and IL‐17A is widely accepted as a regulator for MMP‐2 and MMP‐9.22 As expected, our result showed that IL‐17A up‐regulated the expressions of MMP‐9 and MMP‐2 in a time‐dependent pattern compared to the control group in U251 and U87 cells. This evidence concerns the gene MMP9 and cancer.