Malignant GBMs are primary tumours of the central nervous system characterized by diffuse infiltration into the brain, which are the one of most challenging malignancies to treat in clinic.43 Although there are several studies carried out to investigate the potential role of IL‐17A in the progression of malignant GBMs, the mechanism of IL‐17A could influence glioma progression remains unclear. Here, IL17A is linked to central nervous system cancer.