For example, it has been demonstrated that the up‐regulation of PDX1 is involved in β‐cell reprogramming and neogenesis in adult mice.32 Similarly, transgenic overexpression of PDX1 in STZ‐treated mice can generate new insulin‐producing islet cells.33 All these supported that the up‐regulation of PDX1 may act as a key factor for preservation of β‐cell in diabetes. Here, INS is linked to diabetes mellitus.