Recent evidence also suggests the diminished expression of PGC1α in humans with insulin resistance and diabetes.39 As PGC1α is the master regulator of mitochondrial turnover, restoration of mitophagy by liraglutide can prevent glucolipotoxicity toxicity.40 In the present study, we provide evidence of the ability of liraglutide to inhibit high glucose and high FFA‐induced β‐cell toxicity. Here, PPARGC1A is linked to Insulin resistance.