INS and diabetes mellitus: Glucolipotoxicity, which refers to irreversible damage of chronically elevated levels of circulating glucose and fatty acid, plays an important role in the development of diabetes‐associated complications, particularly in inducing pancreatic β‐cell dysfunction and death.31 Many studies have demonstrated that long‐term exposure of β‐cells to high glucose and high FFA induces dysregulated insulin synthesis and secretion, eventually resulting in apoptosis.