Moreover, it also inhibited the expression of anti‐apoptotic BCL‐2 family proteins such as BCL‐2, BCL‐xL, and MCL‐1.39, 42, 43, 54 Of note, the protective effects of AKT in CLL cells are largely dependent on the activation of the anti‐apoptotic protein MCL‐1.55 The specific mechanisms involved in these inhibitions are not clear and would require further investigations, but suggest that CUDC‐907 has other critical functions apart from the known inhibitory effects on HDACs and PI3K. This evidence concerns the gene AKT1 and B-cell chronic lymphocytic leukemia.