EA down‐regulated CIP2A through reducing CIP2A mRNA expression level (Figure 4), while celastrol induces proteasomal degradation of CIP2A.32 These different mechanisms on CIP2A down‐regulation may explain the synergistic anti‐lung cancers effects of EA in combination with celastrol in vitro and in vivo. Here, CIP2A is linked to lung carcinoma.