Patients carrying a low density of CD8+ TILs had an increased risk for a lower 5-year DFS (HR = 2.16, 95% CI = 1.63–2.86, p < 0.0001), and those with a low tumor CD274 also had an increased risk for a lower 5-year DFS (HR = 1.51, 95% CI = 1.19–1.91, p = 0.0007) compared with patients carrying a high CD8+ TIL count and high tumor CD274 (Table 4). This evidence concerns the gene CD8A and neoplasm.