CD8A and colon carcinoma: The density of CD8+ TILs within the tumor microenvironment was significantly higher in the proximal colon (p = 0.02), nodal metastasis-negative (pN stage-negative, p < 0.0001), early pathological TNM stage (p < 0.0001), poor differentiation (p < 0.0001), absence of perineural invasion (PNI, p < 0.0001), and MMR-deficient (p < 0.0001) colon carcinoma patients (Table 1).