CD8A and neoplasm: Moreover, patients with either a low density of CD8+ TILs or a low tumor CD274 level within the tumor microenvironment presented an increased risk for poor DFS (HR = 1.77, 95% CI = 1.41–2.22, p < 0.0001, Table 5) after adjustment for sex, age, and pT stage, pN stage and tumor location.