Recent reports have demonstrated a direct correlation between the densities of T lymphocyte subpopulations, such as CD8+, CD45RO+ (PTPRC+), and FOXP3+ tumor-infiltrating lymphocytes (TILs), which are associated with a favorable clinical outcome in CRC, supporting a major role of T-cell-mediated immunity in repressing tumor progression of CRC. This evidence concerns the gene FOXP3 and colorectal carcinoma.