We found that genes with depleted levels of expression in organoids (and tumor) were associated with the development and function of retinal neurons [ganglion (POU4F1 (BRN3A), KCNA2, and SCN1A), horizontal and amacrine (TFAP2A (AP2-α) and PAX6), and bipolar (VSX1 and GRM6) cells], Müller glial (RLBP1 and SCL1A3), and retinal progenitor (VSX2 and PAX6) cells (Fig. 4b). The gene discussed is POU4F1; the disease is neoplasm.