PAX6 and neoplasm: In contrast, retinal progenitor (CHX10 and PAX6), ganglion (BRN3 and PAX6), bipolar (CHX10), amacrine (PROX1, AP2-α, and PAX6), and horizontal (PROX1 and PAX6) cells were absent in organoids as indicated by undetectable marker proteins, a finding that concurred with data from tumor tissues (Figs 2n–r’, S1k−o’ and S2k−o’).