Analyzing the quantitative results (Fig. 2), IFN-γ production decreased significantly in recent LTBI at the end of TB preventive therapy, in response to TB1 peptides (baseline: median 4.8, IQR 1.5–10; end of preventive therapy: median 2.1 IQR 0.8–6.5; p = 0.002) and TB2 (baseline: median 6, IQR 1.6–10; end of preventive therapy: median 0.75, IQR 0.07–2; p = 0.001) (Fig. 2A). Here, REEP5 is linked to tuberculosis.