No differences were observed in LTBI with a remote infection in response to TB1 peptides (IFN-γ value at baseline: median 0.33, IQR 0.24–2.47; IFN-γ value at end of preventive therapy: median 0.18, IQR 0–2) and TB2 (IFN-γ value at baseline: median 0.89, IQR 0.41–2.3; IFN-γ value at end of preventive therapy: median 0.32, IQR 0.14–2.68) (Fig. 2B). The gene discussed is REEP5; the disease is infection.