DeBerry et al. reported that the mRNA expression level of TRPA1 in L6–S1 DRGs of mice did not change in response to repeated cyclophosphamide administration14; however, in the same cystitis model, they also observed an upregulation of TRPA1 mRNA expression by single-cell reverse transcription-polymerase chain reaction (RT-PCR) of neuronal cells in L5–S1 DRGs innervating the bladder22. Here, TRPA1 is linked to chronic cystitis.