PTEN and ovarian carcinoma: Subsequently, we defined a higher confidence patient population by differentiating between candidate genes in which the primary role is related to mismatch repair or where, despite a purported role in double-strand DNA repair, either the genetic mechanism is distinct and/or the phenotypic impact on platinum sensitivity and prognosis in ovarian cancer is directionally opposed to that of BRCA mutations (i.e., EMSY amplification and PTEN loss).8