In U57810 cells, which are murine ERMS cells isolated from transgenic p53 null mice in Myf6-positive differentiating myoblasts, the expression of KRAS G12V and small-T-antigen in addition to p16 knockdown led to an increase in Yap/Taz protein levels but there was a proportional increase in Yap S112/Taz S89 phosphorylation. The gene discussed is CDKN2A; the disease is embryonal rhabdomyosarcoma.