Our main finding is that YAP1 S127A and KRAS G12V-Cdkn2a-driven rhabdomyosarcomas only share 20% of the up or down-regulated genes and that the expression of KRAS G12V together with various genetic manipulations of myoblasts does not activate Yap in these cells. The gene discussed is CDKN2A; the disease is rhabdomyosarcoma.