YAP1 and pancreatic ductal adenocarcinoma: For example, in HCTtetK pancreatic adenocarcinoma cells, the expression of a mutant form of YAP1 rescues the expression of 77% of the genes that were decreased following KRAS knockdown14 suggesting that YAP and KRAS mostly regulate the expression of the same set of genes (77%) in pancreatic ductal adenocarcinoma (PDAC).