CDKN2A and neoplasm: Also, KRAS G12V in combination with a Cdkn2a null mutation gives rise to pleomorphic rhabdomyosarcoma with a similar gene expression profile to embryonal rhabdomyosarcoma21 To investigate whether the gene expression in these two types of tumour is similar, we compared the gene expression profiles of the YAP1 S127A-driven ERMS7 with those of KRAS G12V-Cdkn2a null-driven ERMS21.