This analysis revealed substantial differences in up-regulated genes between YAP1 S127A and KRAS G12V-induced rhabdomyosarcomas; approximately 20% (174 genes) of the genes, up-regulated in sarcomas compared to differentiated skeletal muscle, are identical in YAP1 S127A-driven and KRAS G12V-Cdkn2a null-driven ERMS (Fig. 1A). This evidence concerns the gene CDKN2A and rhabdomyosarcoma.