Accordingly, the expression of many key genes in the IFN, NF-κB, and Fas/JNK/Caspase 8 pathways identified in these studies is impaired in TEdeff cancers and cell lines (Fig. 5a, see Fig. 2b–f, and Supplementary Fig 9E for the Hugo et al and Van Allen et al datasets). This evidence concerns the gene FAS and cancer.