As illustrated in Fig. 7, administration of nimbolide after 8 weeks of DMBA painting arrested tumor growth associated with induction of apoptosis and inhibition of autophagy as evidenced by a significant increase in Bax and cleaved caspase-9 and -3 with downregulation of Bcl-2, Beclin, ATG5, and LC-3. This evidence concerns the gene CASP9 and neoplasm.