Consistently, the cleaved p30 form of GSDMD was clearly induced by LPS alone (Fig. 6h) and Z-LEVD decreased IL-1β secretion by LPS-activated monocytes from CAPS patients (Fig. 6f), even more efficiently that in LRZ-stimulated monocytes from healthy donors (see Fig. 1h, j). This evidence concerns the gene IL1B and cryopyrin-associated periodic syndrome.