APPSwe/PS1dE9 (APP/PS1) transgenic mice overexpressing the human mutated APP with Swedish mutation (APP695Swe), and mutant human presenilin 1 with exon 9 deletion (PSEN1dE9), are characterized by age-related memory deficit, anxiety, hyperactivity, and impaired social interaction [55]. Here, PSEN1 is linked to Anxiety.