On the other hand, tumor and stromal cells also secrete proteolytic enzymes that modify the ECM, including MMPs (e.g., MMP-2, -7, -9, -13), A disintegrin and metalloproteinase (e.g., ADAM-8, -10, -12, -15, -17), and a disintegrin and metalloproteinase with thrombospondin motifs (e.g., ADAMTS-1, -8, -13) family members [29,30,31,32]. Here, MMP2 is linked to neoplasm.