MPPE1 and neoplasm: The importance of cDC1 in anti-tumor immunity is underscored by several studies with cDC1-deficient Batf3–/– mice and other in vivo models of cDC1 depletion, which consistently display a loss of the ability to reject transplantable immunogenic tumors and are unable to support T cell–based immunotherapies such as adoptive T cell therapy or immune checkpoint blockade 10, 11, 12, 13, 14.