Indeed, fully differentiated cDC1 recruited from blood or surrounding tissue might be the predominant origin of intratumoral cDC1s that accumulate in response to XCL1 and CCL5 produced by tumor NK cells because cDC1 precursors express only low levels of transcripts for CCR5 and XCR1 [35] (Figure 1). Here, MPPE1 is linked to neoplasm.