The frequency of left atrial (LA)/left atrial appendage (LAA) thrombus formation in patients with AF varies depending on anticoagulation (non vs. anticoagulation), type of treatment (concomitant treatment with acetylsalicylic acid vs. OAC alone), targeted INR values and TTR, type of AF (paroxysmal AF vs. non-paroxysmal AF), LAA morphology (chicken wing vs. non-chicken wing), LA size, increased left ventricular end-diastolic volume, ejection fraction (EF), inappropriate duration of anticoagulation < 3 weeks, metabolic syndrome, diabetes mellitus, CHADS2 and CHA2DS2-VASc score [14–24]. The gene discussed is TTR; the disease is Paroxysmal atrial fibrillation.