F2R and Stroke: The Trial to Assess the Effects of SCH 530348 in Preventing Heart Attack and Stroke in Patients With Atherosclerosis (TRA2°P-TIMI 50) revealed that Vorapaxar, a novel antagonist of protease-activated receptor-1, reduced the rates of hospitalization for acute limb ischemia and peripheral artery revascularization, but did not reduce the risk of cardiovascular death, myocardial infarction, or stroke in patients with stable atherosclerotic vascular disease and LEAD [115].