SMAD3 and nasopharyngeal carcinoma: Since distant metastasis occurs in 20–30% of NPC patients and is the major cause of death in NPC [6], it is noteworthy that we identified 9 genes with enriched tandem 3’UTRs that are involved in the regulation of cell migration; namely SMAD3, JAG1, Pikr1, Ptp4a1, Rac1, RRAS2, Spag9, TRIP6, and TRIB1 (Table 4).