EGFR and non-small cell lung carcinoma: As examples, drugs targeting EGFR kinases (gefitinib, erlotinib or afatinib), both as reversible or irreversible ATP competitors, while producing very high response in patients with EGFR mutated NSCLC, with a significant increase in Progression Free Survival (PFS), the majority of patients relapses with a tumor no more responsive to these drugs [19–21].