<h4>Objective</h4> The aim of the present study was to analyze the expression of the <i>CD63</i>, <i>S100A6</i>, and <i>GNB2L1</i>genes, which participate in mechanisms related to the complex pathophysiology of endometriosis.<h4>Methods</h4> A case-control study was conducted with 40 women who were diagnosed with endometriosis, and 15 fertile and healthy women. Here, RACK1 is linked to endometriosis.