G6PD and G6PD deficiency: Glucose-6-phosphate dehydrogenase deficiency presents clinically in the neonate as jaundice resulting from hyperbilirubinemia; this may lead to kernicterus, a form of brain damage.3,4 Several medications including rasburicase- and 8-aminoquinoline–based antimalarial drugs, such as primaquine, are known to cause clinically significant hemolysis in G6PD-deficient individuals.