Remarkably, important elements in the vanadium mechanism associated with glucose regulation are the glycogen synthesis recovery, the uptake enhancement, and the utilization of glucose; type 1 diabetes models treated with vanadium have shown glycogen increase in muscle and heart, which suggest an improvement in the insulin signaling pathway associated with the reestablishment of the GLUT-4 expression; however, the therapeutic dose must be finely managed [292, 293]. Here, INS is linked to type 1 diabetes mellitus.