Although NF-κB is not directly involved, its participation is very important in metabolic disorders, because NF-κB is involved in increases in chronic liver inflammation, mimics high-fat diet or obesity-induced insulin resistance, and increases pro-inflammatory cytokines such as TNF-α, IL-1, and IL-6 levels, which are critical in the development of insulin resistance or survival cell signaling [361]. The gene discussed is NFKB1; the disease is obesity due to melanocortin 4 receptor deficiency.