However, because this p value was close to being significant, HRs at different time points were calculated, and a slightly decreasing effect of GDF-15 with time was observed (adjusted HRs for diabetes per SD increase in GDF-15 were 1.28 [95% CI 1.13, 1.44] and 1.20 [1.09, 1.33], respectively, at 10 and 20 years of follow-up). The gene discussed is GDF15; the disease is diabetes mellitus.