Xu reported that astragaloside and isoastragaloside in Astragalus root by screening of 50 medical herbs elevated circulating adiponectin levels by enhancing adiponectin production in mouse adipocytes (60), a well-known hormone to reduce risk of obesity, cardiovascular, and diabetic pathophysiology (57, 58). This evidence concerns the gene ADIPOQ and obesity due to melanocortin 4 receptor deficiency.