PTH and Hypocalcemia: He was originally normocalcemic but after the craniosynostosis surgery, he developed severe hypocalcemia, causing a circulatory shock and a disseminated intravascular coagulation that led to a lethal cerebral infarction.19 A second reported child did not have a lethal outcome but a severe form of pseudohypoparathyroidism that is associated with morbid obesity.20 He showed TSH and PTH resistance, diagnosed at the age of 3.6 years, and prothrombotic status.