AD has been describe by a reduction in the levels of the neurotransmitteracetylcholine (ACh), which is hydrolyzed mainly by acetylcholinesterase (AChE) and then by butrylcholinesterase (BuChE) (Racchi, Mazzucchelli, Porrello, Lanni, & Govoni, 2004). The gene discussed is ACHE; the disease is Alzheimer disease.